Background: The aim was to evaluate various detrimental effects of tobacco chewing and smoking on corneal endothelial cells and morphology, as tobacco causes various ocular conditions, including cataract, glaucoma, dry eye, optic neuropathy, age-related macular degeneration and many more. Material and methods: The cross-sectional study was conducted in the ophthalmology department, focusing on individuals who consumed tobacco, through either smoking or chewing. Each group included 100 patients. Specular microscopy was performed to measure the endothelial cell density, coefficient of variation coefficient of variation, and percentage of hexagonal cells. Results: Endothelial cell density and hexagonal cells were significantly higher in non-tobacco users than tobacco users, with p-values < 0.001. Corneal density, left eye coefficient of variation and hexagonal cells comparisons between smokers and tobacco chewers revealed no significant differences, with p-values > 0.05. Only right eye coefficient of variation showed a significant difference, with a p-value < 0.001. Conclusions: This study revealed poor corneal endothelia cell health in smokers and tobacco users. Strict law should be enforced to halt tobacco consumption.