CASE REPORT
Long-term Complications and Treatment after Excision of Periocular Basal Cell Carcinoma – Case Report
More details
Hide details
1
Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Poland
Head: Professor Dorota Wyględowska-Promieńska, MD, PhD
A - Research concept and design; B - Collection and/or assembly of data; C - Data analysis and interpretation; D - Writing the article; E - Critical revision of the article; F - Final approval of article
Submission date: 2024-04-15
Acceptance date: 2024-06-03
Publication date: 2024-10-14
Corresponding author
Michalina Gałuszka
Klinika Okulistyki Katedry Okulistyki Wydziału Nauk Medycznych w Katowicach, Śląski Uniwersytet Medyczny w Katowicach, Poland
Ophthalmology 2024;27(3):5-7
KEYWORDS
TOPICS
ABSTRACT
Introduction: Basal cell carcinoma is the most common malignant skin tumor, accounting for 90% of cases. The most important risk factors include age, male sex, skin phototypes I and II, frequent exposure to the sun, sunburn and positive family history of other skin tumors. More than 75% of basal cell carcinomas occur in the head and neck region. About 20% appear in the periocular region. Case report: A 76-year-old male patient was referred to the Ophthalmology Clinic due to keratopathy of the right eye as a result of postoperative eyelid regurgitation. Eleven years earlier, the patient had undergone surgical excision of basal cell carcinoma in the right temporal region, which resulted in eyelid regurgitation. Anterior segment examination of the right eye revealed symblepharon, eyelid regurgitation, limited mobility and keratopathy. The patient underwent surgery, during which symblepharon lysis, reconstruction of the conjunctival sac with a lower lip mucosa free graft and upper eyelid plasty with a skin graft from the right eyelid were performed. There were no postoperative complications. The mucosal graft healed properly and the patient was able to close his right eyelids. The patient was closely monitored in the clinic for 8 years after the procedure; the local condition of the right eye remained stable. Conclusions: Reconstruction of the eyelids and ocular surface using lip mucosal and skin grafts provides an effective method of eyelid regurgitation and symblepharon treatment, preserving the function of the eyelids and protecting the ocular surface.
REFERENCES (19)
1.
Furdova A, Lukacko P: Periocular Basal Cell Carcinoma Predictors for Recurrence and Infiltration of the Orbit. J Craniofac Surg. 2017 Jan; 28(1): e84–e87. doi: 10.1097/SCS.0000000000003242. PMID: 27906855; PMCID: PMC5266411.
2.
Furdova A, Kapitanova K, Kollarova A, et al.: Periocular basal cell carcinoma – clinical perspectives. Oncol Rev. 2020 Apr 30; 14(1): 420. doi: 10.4081/oncol.2020.420. PMID: 32395200; PMCID: PMC7204832.
3.
van Iersel CA, van de Velden HVN, Kusters CDJ, et al.: Prognostic factors for a subsequent basal cell carcinoma: implications for follow-up. Br J Dermatol. 2005; 153: 1078–1080.
4.
Levi F, Randimbison L, Maspoli M, et al.: High incidence of second basal cell skin cancers. Int J Cancer 2006; 119: 1505–1507.
5.
Ramachandran S, Fryer AA, Lovatt TJ, et al.: Combined effects of gender, skin type and polymorphic genes on clinical phenotype: use of rate of increase in numbers of basal cell carcinomas as a model system. Cancer Lett. 2003; 189: 175–181.
6.
Karagas MR, Stukel TA, Greenberg ER, et al.: Risk of subsequent basal cell carcinoma and squamous cell carcinoma of the skin among patients with prior skin cancer. Skin Cancer Prevention Study Group. JAMA. 1992; 267: 3305–3310.
7.
Lear JT, Tan BB, Smith AG, et al.: Risk factors for basal cell carcinoma in the UK: case-control study in 806 patients. J R Soc Med. 1997; 90: 371–374.
8.
Wallberg P, Kaaman T, Lindberg M: Multiple basal cell carcinoma. A clinical evaluation of risk factors. Acta Derm Venereol. 1998; 78: 127–129.
9.
Saleh GM, Desai P, Collin JRO, et al.: Incidence of eyelid basal cell carcinoma in England: 2000-2010. Br J Ophthalmol. 2017; 101: 209–212.
10.
Sun MT, Wu A, Figueira E, et al.: Management of periorbital basal cell carcinoma with orbital invasion. Future Oncol Lond Engl. 2015; 11: 3003–3010.
11.
Madge SN, Khine AA, Thaller VT, et al.: Globe-sparing surgery for medial canthal Basal cell carcinoma with anterior orbital invasion. Ophthalmology. 2010; 117: 2222–2228.
12.
Leibovitch I, McNab A, Sullivan T, et al.: Orbital invasion by periocular basal cell carcinoma. Ophthalmology. 2005; 112: 717–723.
13.
Sun MT, Wu A, Huilgol SC, et al.: Accuracy of Biopsy in Subtyping Periocular Basal Cell Carcinoma. Ophthal Plast Reconstr Surg, 2015; 31: 449–451.
14.
Newlands C, Currie R, Memon A, et al.: Non-melanoma skin cancer: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016;.130: S125–132.
15.
Shi Y, Jia R, Fan X: Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment. OncoTargets Ther. 2017; 10: 2483–2489.
16.
Furdová A, Horkovičová K, Babál P, et al.: Non-melanotic Tumors of the Eyelids Skin and Inner Corner - Basocellular Carcinoma. Ceska Slov Oftalmol Cas/ Ceske Oftalmol Spolecnosti Slov Oftalmol Spolecnosti. 2015; 71: 293–301.
17.
Ho SF, Brown L, Bamford M, et al.: 5 Years review of periocular basal cell carcinoma and proposed follow-up protocol. Eye. 2013; 27: 78–83.
18.
Honavar SG, Manjandavida FP: Tumors of the ocular surface: A review. Indian J Ophthalmol 2015; 63: 187–203.
19.
Iyer G, Pillai VS, Srinivasan B, et al.: Mucous membrane grafting for lid margin keratinization in Stevens–Johnson syndrome: results. Cornea. 2010; 29: 146–151.