Introduction: Silicon oil-induced glaucoma is a serious complication of the pars plana vitrectomy with a silicon oil tamponade. It arises from mechanisms like silicon oil migration, emulsification, and pre-existing risk factors. This study seeks to provide a comprehensive overview of the existing understanding of this disease, including its diagnosis and novel methods of management, while offering clinical insights. Material and Methods: This study consists of a literature review and a retrospective case series. A comprehensive search was performed across numerous medical databases for studies focusing on silicon oil-induced glaucoma management. Additionally, a case series of 6 patients with silicon oil-induced glaucoma is presented. Results: Articles covering diverse interventions including trabeculectomy, glaucoma drainage devices, Ex-PRESS shunts, and others were identified and summarised. Glaucoma drainage devices demonstrated the most consistent long-term intraocular pressure control. Case series findings aligned with the literature, with the Baerveldt implant achieving sustained intraocular pressure reduction and visual stability in most patients. Conclusions: Intraocular pressure should be closely monitored long-term after silicone oil tamponade, especially in high-risk patients. Silicone oil-induced glaucoma is a multifactorial condition that requires management by clinicians with substantial expertise and familiarity in this specialised area.