Introduction: Primary open-angle glaucoma is a multifactorial chronic neurodegenerative disease. Although the pathogenesis of glaucoma is not fully understood, it is known that the level of intraocular pressure is interconnected with the death of retinal ganglion cells. Neither significant advances in the surgical treatment of glaucoma nor the development of new minimally invasive surgical interventions and a significant expansion of the arsenal of antihypertensive drugs have been able to stop its constant progress. Case report: During the study, the influence of biomarkers LOX1, TGFb2, and pNF-H in the blood plasma of patients with primary open-angle glaucoma before surgery on the frequency of progression of glaucomatous optic neuropathy after anti-glaucomatous surgery was determined. Results: The results obtained indicated a statistically significant dependence of the level of LOX1 in the blood plasma of patients with primary open-angle glaucoma before surgery on the frequency of progression of glaucomatous optic neuropathy after surgical antiglaucoma treatment.