PL EN
PRACA ORYGINALNA
Secondary Glaucoma in Intraocular Tumors
 
Więcej
Ukryj
1
Department of Ophthalmology, Jagiellonian University Medical College, Krakow, Poland
 
2
Ophthalmology Department, University Hospital in Krakow, Poland
 
 
Data nadesłania: 25-08-2025
 
 
Data akceptacji: 09-09-2025
 
 
Data publikacji: 06-11-2025
 
 
Ophthalmology 2025;28(2):15-18
 
SŁOWA KLUCZOWE
STRESZCZENIE
The most common malignant intraocular tumors in adults include uveal melanoma, intraocular metastatic tumors, leukemic infiltrates, and intraocular lymphoma.
Elevated intraocular pressure occurs in approximately 5% of eyes with intraocular tumors. Glaucoma may develop secondary to intraocular tumors in adults through various mechanisms such as drainage angle infiltration, angle closure, or neovascularization. These tumors may be primary (e.g., uveal melanoma) or metastatic. Unilateral or treatment-resistant glaucoma should prompt suspicion of an intraocular tumor. The type and location of an intraocular tumor determine the likelihood of elevated intraocular pressure.
Based on literature data and our own cases, the paper reviews the mechanisms of secondary glaucoma development in the most common intraocular tumors in adults.
REFERENCJE (19)
1.
Shields JA, Augsburger JJ: Prevalence and mechanisms of secondary intraocular pressure elevation in eyes with intraocular tumors. Ophthalmology. 1987; 94(7): 839–846.
 
2.
Romanowska-Dixon B, Jakubowska B: Guzy błony naczyniowej w Onkologia Okulistyczna. PZWL 2019; 105–175.
 
3.
Shields CL, Shields JA, Shields MB, et al.: Prevalence and mechanisms of secondary intraocular pressure elevation in eyes with intraocular tumors. Rationale for therapy in neovascular glaucoma. Trans Ophthalmol Soc UK. 1981; 101: pp. 184–185.
 
4.
Shields CL, Materin MA, Shields JA, et al.: Factors associated with elevated intraocular pressure in eyes with iris melanoma. Br J Ophthalmol. 2001; 85: 666–669.
 
5.
Romanowska-Dixon B, Gerba-Górecka K, Nowak A, et al.: Clinical Characteristics of Choroidal Metastases. Okulistyka. 2024; 3: 11–14.
 
6.
Nguyen QD, Foster CS: Ciliary body melanoma masquerading as chronic uveitis. Ocular Immunol Inflamm.1998; 6: 253–256.
 
7.
Abi-Ayad N, Grange JD, Watkin E, et al.: Ring melanoma revealed by spontaneous hyphema. J Fr Ophtalmol. 2007; 30: 729–732.
 
8.
Nguyen QD, Foster CS, Fraser DJ Jr., et al.: Ocular inflammation and hemorrhage as initial manifestations of uveal malignant melanoma. Incidence and prognosis. Arch Ophthalmol. 1979; 97: 1311–1314.
 
9.
Haimovici R, Mukai S, Schachat AP, et al.: Rhegmatogenous retinal detachment in eyes with uveal melanoma. Retina. 1996; 16: 488–496.
 
10.
Damato BE, Foulds WS: Tumor-associated retinal pigment epitheliopathy. Eye. 1990; 4(Pt 2): 382–387.
 
11.
Nelson CC, Hertzberg BS, Klintworth GK: A histopathologic study of 716 unselected eyes in patients with cancer at the time of death. Am J Ophthalmol. 1983; 95: 788–793.
 
12.
Sneed SR, Byrne SF, Mieler WF, et al.: Choroidal detachment associated with malignant choroidal tumors. Ophthalmology. 1991; 98: 963–970.
 
13.
Nguyen QD, Foster CS: Ciliary body melanoma masquerading as chronic uveitis. Ocular Immunol Inflamm. 1998; 6: 253–256.
 
14.
Markiewicz A, Gerba-Górecka K, Jakubowska B, et al.: Brachytherapy or enucleation in ring melanoma patients: which is better? Preliminary results of the authors’ own experiences. J Contemp Brachytherapy. 2021; 13, 4: 433–440 DOI: https://doi.org/10.5114/jcb.20....
 
15.
Shields CL: Iris Metastasis From Systemic Cancer in 104 Patients: The 2014 Jerry A. Shields Lecture. Cornea. 2015 Jan; 34(1): 42–48.
 
16.
Gerba-Górecka K, Romanowska-Dixon B, Karska-Basta I, et al.: Clinical characteristic and management of ocular metastases. Cancers. 2025; 17(6): 1041–1050; https://doi.org/10.3390/cancer....
 
17.
Schuman JS, Wang N, Eisenberg DL: Leukemic glaucoma: the effects on outflow facility of chronic lymphocytic leukemia lymphocytes. Exp Eye Res. 1995; 61(5): 609–617.
 
18.
Velez G, de Smet MD, Whitcup SM, et al.: Iris involvement in primary intraocular lymphoma: report of two cases and review of the literature. Surv Ophthalmol. 2000 May-Jun; 44(6): 518–526.
 
19.
Cooper EL, Riker JL: Malignant Lymphoma of the Uveal Tract. Am J Ophthalmol. 1951 Aug; 34(8): 1153–1158.
 
eISSN:1689-362X
ISSN:1505-2753
Journals System - logo
Scroll to top